Efectos hipotensivos del Agaricus blazei Murill o champiñón del Sol en personas con la tensión elevada o medianamente elevada
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De La enciclopedia sobre el Agaricus blazei Murill
KOBAYASHI HITOSHI, INATOMI SATOSHI, OUCHI KENJI, AZUMI YOSHIHITO, TSUCHIDA TAKASHI. Hypotensive Effects and Safety of Extracts Squeezed from Agaricus blazei on High-normal Blood Pressure and Mild Hypertensive Subjects. Japanese Pharmacology & Therapeutics. VOL.34; NO.12; PAGE. 1323-1341(2006)
(Efectos hipotensivos del Agaricus blazei Murill o champiñón del Sol en personas con la tensión elevada o medianamente elevada).
Palabras clave: hipertensión, (Hipertensión)
Resumen (en inglés):
To investigate hypotensive effects and safety in the long term ingestion of extracts squeezed from Agaricus blazei(ABFE)containing .GAMMA.-aminobutyric acid(GABA)which is expected hypotensive effect in hypertensive persons, we conducted double-blind, placebo-controlled study on high normal blood pressure and mild hypertensive subjects to the number of 80(mean age, 46). Group A (n=40)ingested 50mL of placebo water non-containing GABA as placebo-control, and group B(n=40)ingested 50mL of ABFE containing 40mg of GABA for 12 weeks consecutively. In group B, systolic blood pressures of high normal blood pressure subjects decreased significantly at 4 weeks after ingest initiation compared with that of group A(p<0.01), and diastolic blood pressure decreased significantly at 8 weeks after ingest initiation compared with that of group A(p<0.01). In mild hypertensive subjects of group B, both systolic and diastolic blood pressures decreased significantly at 6 weeks or 4weeks after ingest initiation compared with those of group A, respectively(p<0.05, p<0.01, respectively). Furthermore, when the ABFE ingestion was stopped at 12 weeks after ingest initiation, systolic and diastolic blood pressures of all subjects in the group B were increased gradually. In addition, abnormalities in subjective symptom, interview by medical doctors, blood test, biochemical test and urinary test were not observed in all of subjects during the study period. These results suggest that the ABFE containing 40 mg of GABA causes reduction of systolic and diastolic blood pressures of high normal blood pressure and mild hypertensive persons in the long-term ingestion, and the ABFE is safety food.
