La actividad de las células Natural killer y la calidad de vida se mejoraron por el consumo de un extracto de una seta, el Agaricus blazei Murill Kyowa, en pacientes de cáncer ginecológicos bajo quimioterapia
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Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94.
(La actividad de las células Natural killer y la calidad de vida se mejoraron por el consumo de un extracto de una seta, el Agaricus blazei Murill Kyowa, en pacientes de cáncer ginecológicos bajo quimioterapia)
Palabras clave: células NK - Natural Killers, quimioterapia, distintos tipos de Agaricus blazei, neoplasias genitales, cánceres ginecológicos, variedad de Agaricus blazei Murill Kyowa - cepa K22
Resumen: (en inglés)
Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. ahnws@catholic.ac.kr
A mushroom extract, Agaricus blazei Murill Kyowa (ABMK), has been reported to possess antimutagenic and antitumor effects. Here, we investigate the beneficial effects of ABMK consumption on immunological status and qualities of life in cancer patients undergoing chemotherapy. One hundred cervical, ovarian, and endometrial cancer patients were treated either with carboplatin (300 mg / m(2)) plus VP16 (etoposide, 100 mg / m(2)) or with carboplatin (300 mg / m(2)) plus taxol (175 mg / m(2)) every 3 weeks for at least three cycles with or without oral consumption of ABMK. We observed that natural killer cell activity was significantly higher in ABMK-treated group (ANOVA, n = 39, P < 0.002) as compared with nontreated placebo group (n = 61). However, no significant difference in lymphokine-activated killer and monocyte activities was observed in a manner similar to the count of specific immune cell populations between ABMK-treated and nontreated groups. However, chemotherapy-associated side effects such as appetite, alopecia, emotional stability, and general weakness were all improved by ABMK treatment. Taken together, this suggests that ABMK treatment might be beneficial for gynecological cancer patients undergoing chemotherapy.
